Biotinyl-methyl 4-(amidomethyl)benzoate is a competitive inhibitor of human biotinidase
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Biotinyl-methyl 4-(amidomethyl)benzoate is a competitive inhibitor of human biotinidase.
Posttranslational modification of histones by biotinylation can be catalyzed by both biotinidase (BTD) and holocarboxylase synthetase. Biotinylation of histones is an important epigenetic mechanism to regulate gene expression, DNA repair, and chromatin remodeling. The role of BTD in histone biotinylation is somewhat ambiguous, given that BTD also catalyzes removal of the biotin tag from histone...
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ژورنال
عنوان ژورنال: The Journal of Nutritional Biochemistry
سال: 2008
ISSN: 0955-2863
DOI: 10.1016/j.jnutbio.2007.11.002